Induction of liver tumors in female Sherman strain rats by polybrominated biphenyls.

Abstract

Noninbred Sherman strain rats were given the polybrominated biphenyl mixture Firemaster FF-1 (PBB). Rats given a single dose of 1,000 mg PBB/kg or 12 doses of 100 mg PBB/kg body weight in corn oil by gavage had final (when less than or equal to 26 mo old) liver PBB concentrations of 17.1 and 34.8 mg/kg (wet wt), respectively. The respective incidence of hepatocellular carcinomas was 41.4 and 67.8%. No difference in PBB concentrations was found between hepatocellular carcinomas and surrounding liver tissue. In addition, most livers of PBB-dosed rats had adenofibrosis of the liver. Livers of controls were essentially normal. Rats given a single dose of 200 mg PBB/kg as above had a 31.2% incidence of neoplastic nodules, whereas none were seen in the controls. The mean PBB concentrations (when 26 mo old) were 2.68 mg/kg in liver, 244 mg/kg in adipose tissue, and 0.22 mg/kg in blood.

• Authors: R D Kimbrough, D F Groce, M P Korver, V W Burse
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 66 Issue 3 Pg. 535-42 (Mar 1981) ISSN: 0027-8874 [Print] United States
• PMID: 6259400 (Publication Type: Journal Article)

Chemical References

• Biphenyl Compounds
• Polybrominated Biphenyls

Topics

• Adipose Tissue (metabolism)
• Animals
• Biphenyl Compounds (toxicity)
• Body Weight (drug effects)
• Female
• Liver (drug effects, metabolism)
• Liver Neoplasms (chemically induced, pathology)
• Liver Neoplasms, Experimental (chemically induced, pathology)
• Pituitary Neoplasms (chemically induced)
• Polybrominated Biphenyls (metabolism, toxicity)
• Rats