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Anti-tremor action of C10Dichol, a peripheral acetylcholine synthesis inhibitor.

Abstract
1 Anti-tremor action of decamethylene bis-(hydroxyethyl)-dimethylammonium bromide (C10Dichol), a peripheral acetylcholine synthesis inhibitor, was investigated. 2 C10Dichol inhibited tremor induced by oxotremorine, nicotine and physostigmine and afforded partial protection from physostigmine-induced mortality in mice. 3 In non-paralysing doses, C10Dichol antagonized the neuromuscular effects of oxotremorine, nicotine and physostigmine. 4 Prior administration of C10Dichol failed to prevent tremor and neuromuscular paralysis induced by harmine and arecoline. 5 In the absence of any antimuscarinic property of C10Dichol, its neuromuscular effects appeared to be casually related to its anti-tremor action. 6 This study reveals a possibility for the development of peripherally acting anti-Parkinson drugs.
AuthorsM Das, D K Ganguly, J R Vedasiromoni
JournalBritish journal of pharmacology (Br J Pharmacol) Vol. 71 Issue 1 Pg. 349-53 ( 1980) ISSN: 0007-1188 [Print] England
PMID6258692 (Publication Type: Journal Article)
Chemical References
  • Quaternary Ammonium Compounds
  • C10-Dichol
  • Physostigmine
  • Acetylcholine
Topics
  • Acetylcholine (biosynthesis)
  • Animals
  • Anura
  • Blood Pressure (drug effects)
  • Electrocardiography
  • In Vitro Techniques
  • Mice
  • Muscle Contraction (drug effects)
  • Muscle, Smooth (drug effects)
  • Physostigmine (toxicity)
  • Quaternary Ammonium Compounds (pharmacology)
  • Rats
  • Synaptic Transmission (drug effects)
  • Tremor (prevention & control)

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