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Is type 1b glycogenosis related to an anomeric preference for glucose-6-phosphate uptake by hepatic microsomes?

Abstract
The contradictory data obtained in studies of type 1b glycogenosis would be explained by an anomeric preference for the capture of glucose-6-phosphate by hepatic microsomes. The alpha anomers of hexoses would be utilized preferentially by glycogenolysis and gluconeogenesis, while the beta anomers of hexoses would be preferentially utilized for glycolysis.
AuthorsP P Kamoun
JournalMedical hypotheses (Med Hypotheses) Vol. 6 Issue 11 Pg. 1135-9 (Nov 1980) ISSN: 0306-9877 [Print] United States
PMID6256613 (Publication Type: Journal Article)
Chemical References
  • Glucosephosphates
  • Glycogen
  • Glucose-6-Phosphatase
Topics
  • Gluconeogenesis
  • Glucose-6-Phosphatase (metabolism)
  • Glucosephosphates (metabolism)
  • Glycogen (metabolism)
  • Glycogen Storage Disease Type I (metabolism)
  • Glycolysis
  • Humans
  • Microsomes, Liver (metabolism)
  • Models, Biological
  • Permeability
  • Stereoisomerism
  • Structure-Activity Relationship

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