Postirradiation malignant fibrous histiocytoma of the lung. Demonstration of alpha 1-antitrypsin-like material in neoplastic cells.

Abstract

A metastasizing fibrous histiocytoma arising in the lung of a patient who received radiation therapy and long-term chemotherapy for malignant lymphoma is presented. Ultrastructural studies revealed fibroblast-like and histiocyte-like cells, cells of intermediate type showing ultrastructural features of both fibroblast-like and histiocyte-like cells, primitive mesenchymal cells, multinucleate tumor cells, and xanthomatous cells. The neoplastic cells showed dilated rough endoplasmic reticula with intracisternal accumulation of electron-dense material forming lattice-like structures. Direct immunofluorescence staining of the neoplastic cells using antihuman alpha 1-antitrypsin showed specific activity, with fluorescent deposits exhibiting interlacing globular formations. These findings and their implications are discussed.

• Authors: L N Chowdhury, M A Swerdlow, W Jao, S Kathpalia, R K Desser
• Journal: American journal of clinical pathology (Am J Clin Pathol) Vol. 74 Issue 6 Pg. 820-6 (Dec 1980) ISSN: 0002-9173 [Print] England
• PMID: 6255791 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• alpha 1-Antitrypsin

Topics

• Female
• Histiocytoma, Benign Fibrous (etiology, metabolism, pathology)
• Histocytochemistry
• Humans
• Liver Neoplasms (secondary)
• Lung Neoplasms (etiology, metabolism, pathology)
• Lymphoma (drug therapy, radiotherapy)
• Middle Aged
• Neoplasms, Radiation-Induced
• alpha 1-Antitrypsin (metabolism)