Histopathology of carcinomas of the liver in mice fed perthane.

Abstract

B6C3F1 female mice fed an average dose of 3,000 ppm of perthane for 2 years developed a highly significant incidence of hepatocellular carcinomas of the liver. Male mice fed 2,500 ppm perthane had a slight increase of carcinoma of the liver. Some of the carcinomas were well-differentiated; however, most were poorly differentiated or undifferentiated. Perthane-treated mice also had well and poorly differentiated cholangiocarcinomas and carcinosarcomas, neoplasms not seen in control mice.

• Authors: M D Reuber
• Journal: Tumori (Tumori) Vol. 66 Issue 3 Pg. 277-83 (Jun 30 1980) ISSN: 0300-8916 [Print] United States
• PMID: 6255646 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• perthane
• Dichlorodiphenyldichloroethane

Topics

• Adenoma, Bile Duct (chemically induced)
• Animals
• Body Weight (drug effects)
• Dichlorodiphenyldichloroethane (analogs & derivatives, toxicity)
• Female
• Liver Neoplasms (chemically induced, pathology)
• Liver Neoplasms, Experimental (chemically induced, pathology)
• Male
• Mice
• Sex Factors