[Ionic currents of neuroblastoma clone N18 A-1 cultured cells under potassium fluoride and phosphate intracellular dialysis].

Abstract

Ionic currents of cells of neuroblastoma clone N18 A-1 was studied under conditions when the internal medium was placed for artificial fluoride or phosphate solutions. The specific membrane leakage resistance was measured to be 8.1 +/- 2.6 kOhm.cm2 and 1.3 +/- 0.3 Kohm.cm2, respectively. The presence of usual sodium and tetraethylammonium sensitive potassium channels is demonstrated. Potassium conductance is shown to amount to 0.25--0.025 of sodium conductance. Dialysis of the cells by phosphate solutions induces a slow outward current, which is not inhibited by tetraethylammonium ions.

• Authors: A N Zubov, A P Naumov, B Kh Nisman
• Journal: Tsitologiia (Tsitologiia) Vol. 22 Issue 10 Pg. 1200-6 (Oct 1980) ISSN: 0041-3771 [Print] Russia (Federation)
• Vernacular Title: Ionnye toki kul'tiviruemykh kletok neĭroblastomy klona N18 A-1 v usloviiakh vnutrikletochnogo dializa ftoridom i fosfatom kaliia.
• PMID: 6255643 (Publication Type: English Abstract, Journal Article)

Chemical References

• Ion Channels
• Phosphates
• Fluorides
• Potassium

Topics

• Animals
• Cell Line
• Cells, Cultured
• Clone Cells (metabolism)
• Dialysis (methods)
• Electric Conductivity
• Fluorides (pharmacology)
• Ion Channels (drug effects)
• Mice
• Neoplasms, Experimental (metabolism)
• Neuroblastoma (metabolism)
• Phosphates (pharmacology)
• Potassium (metabolism)