Hypokinesia produced by anterolateral hypothalamic 6-hydroxydopamine lesions and its reversal by some antiparkinson drugs.

Abstract

Hypokinesia produced by stereotaxic microinjection of solutions of 6-hydroxydopamine into the anterolateral hypothalamus of male rats is accompanied by a generalized reduction in brain noradrenaline levels and a reduction of dopamine in the striatum and cerebral cortex. The hypokinesia is reversed by the putative dopamine-receptor agonists apomorphine, ET-495 and CB-154 as well as by the amino acids L-Dopa and m-tyrosine when administered in combination with the peripheral decarboxylase inhibitor Ro 4-4602. The relative importance of noradrenergic and dopaminergic systems in the mediation of the action of anti-akinesia drugs is discussed.

• Authors: R F Butterworth, F Bélanger, A Barbeau
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 8 Issue 1 Pg. 41-5 (Jan 1978) ISSN: 0091-3057 [Print] United States
• PMID: 625480 (Publication Type: Journal Article)

Chemical References

• Antiparkinson Agents
• Hydroxydopamines
• Receptors, Dopamine
• Serotonin
• Bromocriptine
• Tyrosine
• Levodopa
• Piribedil
• Apomorphine
• Dopamine
• Norepinephrine

Topics

• Animals
• Antiparkinson Agents (pharmacology)
• Apomorphine (pharmacology)
• Brain (metabolism)
• Bromocriptine (pharmacology)
• Dopamine (metabolism)
• Hydroxydopamines (adverse effects)
• Hypothalamus (physiology)
• Hypothalamus, Anterior (drug effects, physiology)
• Levodopa (pharmacology)
• Male
• Models, Neurological
• Motor Activity (drug effects, physiology)
• Norepinephrine (metabolism)
• Piribedil (pharmacology)
• Rats
• Receptors, Dopamine (drug effects)
• Serotonin (metabolism)
• Tyrosine (pharmacology)