Response of mibolerone-treated chickens to infectious bursal disease virus.

Abstract

The response of mibolerone-treated chickens to infectious bursal disease virus (IBDV) was studied. Chickens fed a ration containing mibolerone at 1.5 parts per million (ppm) developed bursal atrophy by 4 weeks of age. No indication was found that mibolerone prevented IBDV infection even after 7 weeks of feeding. Furthermore, only chickens treated with mibolerone died when infected with IBDV at 2 or 3 weeks of age, and treated chickens had more severe clinical signs than did untreated controls when infected at 4-8 weeks of age. Chickens fed mibolerone had lower body weights than unmedicated controls, and apparently had a lower antibody response to IBDV and to bovine serum albumin.

• Authors: B Lucio, S B Hitchner
• Journal: Avian diseases (Avian Dis) 1980 Apr-Jun Vol. 24 Issue 2 Pg. 334-44 ISSN: 0005-2086 [Print] United States
• PMID: 6254486 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Nandrolone
• mibolerone

Topics

• Animals
• Antibodies, Viral (analysis)
• Antibody Formation
• Body Weight
• Bursa of Fabricius (drug effects)
• Chickens
• Female
• Immunization, Passive
• Infectious bursal disease virus (immunology)
• Male
• Nandrolone (analogs & derivatives, pharmacology)
• Poultry Diseases (prevention & control)
• Reoviridae Infections (prevention & control, veterinary)