The induction of immunoblastic T cell sarcomas by virus-transformed prothymocytes.

Abstract

The ontogeny of thymus-dependent lymphoid tumors induced by murine sarcoma-murine leukemia virus (MSV-MuLV) was investigated. Tumors that developed in spleens of infected mice 6 or more months after the injection of virus were diagnosed as immunoblastic T cell sarcomas. Cells derived from the tumors and established as a continuous cell line expressed the thymus leukemia (TL), brain-associated theta (BAT), and Qa2 cell surface antigens but lacked either the Ly 1 or Ly 2, 3 mature T cell differentiation antigens. In addition, the tumor cell expressed c type viral antigens, and had receptors for the lectin peanut agglutinin. The tumor cells were inert when tested for their capacity to respond in several functional T cell assays. Taken together, these data support the hypothesis that the primary target of malignant transformation by MSV-MuLV is a prothymocyte.

• Authors: C L Reinisch, S E Kurtz, E A Morris, A Lampert
• Journal: The American journal of pathology (Am J Pathol) Vol. 101 Issue 2 Pg. 265-82 (Nov 1980) ISSN: 0002-9440 [Print] United States
• PMID: 6254363 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Surface
• Antigens, Viral
• Lectins
• Receptors, Immunologic

Topics

• Animals
• Antigens, Surface (immunology)
• Antigens, Viral (immunology)
• Cell Transformation, Viral
• Female
• Lectins (immunology)
• Leukemia Virus, Murine (immunology)
• Lymphoma (immunology, physiopathology)
• Mice
• Receptors, Immunologic (analysis)
• Sarcoma Viruses, Murine (immunology)
• Sarcoma, Experimental (immunology, physiopathology)
• Splenic Neoplasms (immunology, physiopathology)
• T-Lymphocytes (immunology)