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A preliminary study of cyclophosphamide (NSC-26271), adriamycin (NSC-123127), imidazole carboxamide (NSC-45388), and actinomycin D (NSC-3053) with or without MER-BCG in patients with advanced sarcomas.

Abstract
Polychemotherapy for soft tissue sarcomas has been reported to produce response rates ranging from 24--60% (1, 2). Immunotherapy has reportedly prolonged survival after surgery for some tumors and enhanced the effectiveness of chemotherapy (3, 4). This report summarizes our preliminary experience with the combination of cyclophosphamide, adriamycin, imidazole carboxamide (DTIC), and actinomycin D (CAIA) with or without methanol extraction residue of BCG (MER) in patients with advanced sarcomas.
AuthorsE T Creagan, J H Edmonson, R G Hahn, D L Ahmann, H F Bisel, R T Eagan
JournalMedical and pediatric oncology (Med Pediatr Oncol) Vol. 4 Issue 1 Pg. 85-6 ( 1978) ISSN: 0098-1532 [Print] United States
PMID625266 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antineoplastic Agents
  • BCG Vaccine
  • Dactinomycin
  • Dacarbazine
  • Doxorubicin
  • Cyclophosphamide
  • Methanol
Topics
  • Adult
  • Antineoplastic Agents (therapeutic use)
  • BCG Vaccine (isolation & purification, therapeutic use)
  • Cyclophosphamide (therapeutic use)
  • Dacarbazine (therapeutic use)
  • Dactinomycin (therapeutic use)
  • Doxorubicin (therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Methanol
  • Neoplasm Metastasis (therapy)
  • Remission, Spontaneous
  • Sarcoma (therapy)

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