Effects of prostaglandin D3 on nerve transmission in nictitating membrane of cats.

Abstract

In anesthetized cats, intra-arterial injection of PGD3 toward the nictitating membrane caused long-lasting, dose-related decreases in the response of the nictitating membrane to sympathetic nerve stimulation. During peak depression of nerve transmission the response of the nictitating membrane to intra-arterial norepinephrine was not depressed suggesting that PGD3 suppressed the release of norepinephrine. PGD3 was as potent as PGD2 for modulating sympathetic nerve transmission but was less effective in activating a vagally mediated bradycardia. The results show that the PGD3 can modulate autonomic nerve transmission.

• Authors: D P Hemker, J W Aiken
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 67 Issue 1 Pg. 155-8 (Oct 03 1980) ISSN: 0014-2999 [Print] Netherlands
• PMID: 6252026 (Publication Type: Journal Article)

Chemical References

• Prostaglandins
• Prostaglandins D
• prostaglandin D3

Topics

• Animals
• Cats
• Hemodynamics (drug effects)
• Muscle Contraction (drug effects)
• Nictitating Membrane (drug effects)
• Prostaglandins (pharmacology)
• Prostaglandins D (pharmacology)
• Synaptic Transmission (drug effects)