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Inhibition of hypersensitivity reactions by 16(S)-methyl-20-methoxy-PGE2 (YPG-209) in animals.

Abstract
The effects of 16(S)-methyl-20-methoxy-PGE2 (YPG-209) on hypersensitivity reactions were investigated in the rat, guinea-pig and mouse. Intravenously administered YPG-209 was 150 times as potent as disodium cromoglycate (DSCG) in the inhibitory effect on the IgE(mouse)-mediated 24 hr rat PCA. When administered intravenously to guinea-pigs, YPG-209 inhibited significantly the IgE (guinea-pig)-mediated 8 day guinea-pig PCA, whereas DSCG exhibited no significant inhibitory effects. The oral doses of YPG-209 diminished both histamine and 5-hydroxytryptamine hypersensitivity of the Bordetella pertussis-treated mice. These results suggest that YPG-209 exhibits not only the prevention of mediator release but also the antimediator effect in laboratory animals.
AuthorsK Tomioka, H Maeno
JournalArchives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 244 Issue 1 Pg. 157-65 (Mar 1980) ISSN: 0003-9780 [Print] Belgium
PMID6251764 (Publication Type: Journal Article)
Chemical References
  • Prostaglandins E, Synthetic
  • Serotonin
  • 16-methyl-20-methoxy-PGE2
  • Histamine
  • Dinoprostone
Topics
  • Animals
  • Bordetella pertussis (immunology)
  • Dinoprostone (analogs & derivatives)
  • Drug Hypersensitivity (prevention & control)
  • Female
  • Histamine (pharmacology, toxicity)
  • Hypersensitivity (prevention & control)
  • Mice
  • Passive Cutaneous Anaphylaxis (drug effects)
  • Prostaglandins E, Synthetic (pharmacology)
  • Serotonin (pharmacology)

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