Abstract |
The effects of 16(S)-methyl-20-methoxy-PGE2 (YPG-209) on hypersensitivity reactions were investigated in the rat, guinea-pig and mouse. Intravenously administered YPG-209 was 150 times as potent as disodium cromoglycate (DSCG) in the inhibitory effect on the IgE(mouse)-mediated 24 hr rat PCA. When administered intravenously to guinea-pigs, YPG-209 inhibited significantly the IgE (guinea-pig)-mediated 8 day guinea-pig PCA, whereas DSCG exhibited no significant inhibitory effects. The oral doses of YPG-209 diminished both histamine and 5-hydroxytryptamine hypersensitivity of the Bordetella pertussis-treated mice. These results suggest that YPG-209 exhibits not only the prevention of mediator release but also the antimediator effect in laboratory animals.
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Authors | K Tomioka, H Maeno |
Journal | Archives internationales de pharmacodynamie et de therapie
(Arch Int Pharmacodyn Ther)
Vol. 244
Issue 1
Pg. 157-65
(Mar 1980)
ISSN: 0003-9780 [Print] Belgium |
PMID | 6251764
(Publication Type: Journal Article)
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Chemical References |
- Prostaglandins E, Synthetic
- Serotonin
- 16-methyl-20-methoxy-PGE2
- Histamine
- Dinoprostone
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Topics |
- Animals
- Bordetella pertussis
(immunology)
- Dinoprostone
(analogs & derivatives)
- Drug Hypersensitivity
(prevention & control)
- Female
- Histamine
(pharmacology, toxicity)
- Hypersensitivity
(prevention & control)
- Mice
- Passive Cutaneous Anaphylaxis
(drug effects)
- Prostaglandins E, Synthetic
(pharmacology)
- Serotonin
(pharmacology)
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