Abstract |
Because of the crucial practical importance of combined injuries, investigations of the efficacy of the radioprotective agent aminopropylamino-ethylthiophosphate ( WR 2721) were performed on mice which were whole-body X-irradiated and stressed with a second trauma either as an open wound or as burn wounds on the skin. In cases of sole whole-body irradiation, probit analyses of our data yielded the dose reduction factors (DRF) of 2.42 (NMRI-Hannover) and 2.12 (NMRI-Kisslegg). In case of a combination of an open skin wound (SW) with irradiation in mice of the Hannover breed the following dose reduction factors have been obtained: for irradiation+SDW 10 min p. r. the DRF 2.22, for irradiation+SW 2 d p. r. the DRF 2.30, and for irradiation+SW 8 d p. R.. the DRF 2.29. In cases of combined injuries with two burn wounds (BW) as second trauma in mice of the Kissblegg breed yielded: the DRF 2.01 for irradiation+BW 10 min p. r., and the DRF 1.91 for irradiation+BW 2 d p. r. The protective effect of WR 2721 is apparently similar in the various groups with combined injuries as compared to the animals exposed to whole-body irradiation only. The mechanisms of action of the sulphur-containing radioprotective agents are discussed.
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Authors | H Sedlmeier, O Messerschmidt |
Journal | Strahlentherapie
(Strahlentherapie)
Vol. 156
Issue 8
Pg. 572-8
(Aug 1980)
ISSN: 0039-2073 [Print] Germany |
Vernacular Title | Untersuchungen über Kombinationsschäden, 29. Mitteilung. Schutzeffekt von Aminopropylamino-äthylthiophosphat (WR 2721) bei strahlen- und kombinationsgeschädigten Mädigten Mäusen (Bestrahlung plus Hautwunde bzw. Verbrennung). |
PMID | 6251580
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Organothiophosphorus Compounds
- Amifostine
|
Topics |
- Amifostine
(therapeutic use)
- Animals
- Burns
(drug therapy)
- Female
- Mathematics
- Mice
- Organothiophosphorus Compounds
(therapeutic use)
- Radiation Dosage
- Radiation Injuries
(drug therapy)
- Wounds and Injuries
(drug therapy)
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