Differentiative and proliferative effects of (But)2cAMP, n-butyric acid and prednisolone on the malignant melanoma cell line (TM-1) in vitro and in vivo.

Abstract

Both (But)2cAMP and n-butyric acid suppressed the proliferation of TM-1 cells and induced the formation and elongation of the cellular processes in vitro. Prednisolone stimulated the proliferation of TM-1 cells and increased the number of polygonal cells in vitro. These results indicated that (But)2cAMP and n-butyric acid induce the differentiation of TM 1 cells, whereas prednisolone brings the cells in an undifferentiated state. The growth of TM-1 cell tumor transplanted into nude mice was suppressed by 5 mg of (But)2cAMP and 1 mg of theophylline. Remarkable histological changes were seen in the tumors treated with these agents as compared with untreated tumors. This suggests that (But)2cAMP suppresses the proliferation of TM-1 cells in vivo.

• Authors: M Kimura, T Nishihira, M Kasai, H Sato
• Journal: The Tohoku journal of experimental medicine (Tohoku J Exp Med) Vol. 131 Issue 1 Pg. 29-35 (May 1980) ISSN: 0040-8727 [Print] Japan
• PMID: 6250249 (Publication Type: Journal Article)

Chemical References

• Butyrates
• Bucladesine
• Prednisolone
• Theophylline

Topics

• Animals
• Bucladesine (pharmacology, therapeutic use)
• Butyrates (pharmacology)
• Cell Differentiation (drug effects)
• Cell Division (drug effects)
• Cell Line
• Melanoma (drug therapy, pathology)
• Mice
• Neoplasms, Experimental (drug therapy)
• Prednisolone (pharmacology)
• Theophylline (therapeutic use)