Interaction of the antiallergic agent AA-344 with biogenic amines and prostaglandins in production of cyclic AMP in rat mast cells.

Abstract

AA-344, which has been evidenced to inhibit selectively IgE-mediated allergic reactions, exhibited an inhibitory effect on cyclic AMP phosphodiesterase (PDase) in the homogenates of purified rat peritoneal mast cells (RMC). AA-344 showed synergistic effects with epinephrine, isoproterenol or prostaglandin E2 and F2 alpha in increasing cyclic AMP level in RMC: the combinations caused an increase in cyclic AMP 30-160 times as much as that caused by the respective agent alone. In the latter effect, AA-344 was at least 1,000 times as potent as theophylline. On the other hand, histamine or serotonin with or without AA-344 had no effect on the RMC cyclic AMP. These results obtained in vitro suggest that AA-344 may exert antiallergic action by increasing cyclic AMP via an interaction with epinephrine or prostaglandins which might be endogenously involved in regulation of a function of RMC in allergic reactions.

• Authors: Y Ashida, T Saijo, H Kuriki, Y Maki
• Journal: International archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 62 Issue 4 Pg. 415-22 ( 1980) ISSN: 0020-5915 [Print] Switzerland
• PMID: 6247289 (Publication Type: Journal Article)

Chemical References

• Amines
• Chromones
• Phosphodiesterase Inhibitors
• Prostaglandins
• Tetrazoles
• Serotonin
• 6-ethyl-3-(1H-tetrazol-5-yl)chromone
• Histamine
• Theophylline
• Cyclic AMP
• Isoproterenol
• Epinephrine

Topics

• Amines (pharmacology)
• Animals
• Chromones (pharmacology, therapeutic use)
• Cyclic AMP (biosynthesis)
• Drug Synergism
• Epinephrine (pharmacology)
• Histamine (pharmacology)
• Hypersensitivity (drug therapy)
• Isoproterenol (pharmacology)
• Male
• Mast Cells (metabolism)
• Phosphodiesterase Inhibitors
• Prostaglandins (pharmacology)
• Rats
• Serotonin (pharmacology)
• Tetrazoles (pharmacology, therapeutic use)
• Theophylline (pharmacology)