Expression of peanut agglutinin receptors on virus-induced preleukemic cells in mice.

Abstract

Preleukemic bone marrow and spleen cells of irradiated C57BL/6 mice that were inoculated with the radiation-induced leukemia virus variant D-RadLV differ from autonomous end-stage leukemia cells in the expression of the receptor for peanut agglutinin. As a result, the preleukemic cells are agglutinated by peanut agglutinin and the end-stage cells are not. This observation provides further evidence that preleukemic cells possess surface markers similar to those of the prothymocyte. In vitro and in vivo thymocyte-virus interactions reveal that cells susceptible to D-RadLV transformation are present mainly among the peanut agglutinin-receptor-bearing thymocyte population which has previously been demonstrated to be immunologically immature.

• Authors: Y Reisner, N Sharon, N Haran-Ghera
• Journal: Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 77 Issue 4 Pg. 2244-6 (Apr 1980) ISSN: 0027-8424 [Print] United States
• PMID: 6246529 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Lectins
• Plant Lectins
• Receptors, Drug

Topics

• Animals
• Arachis
• Bone Marrow (metabolism)
• Lectins (metabolism)
• Leukemia Virus, Murine
• Mice
• Plant Lectins
• Preleukemia (metabolism)
• Receptors, Drug (metabolism)
• Spleen (metabolism)
• Thymus Gland (metabolism)