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Methotrexate with citrovorum factor rescue: reduced chemotherapy toxicity in the management of gestational trophoblastic neoplasms.

Abstract
The comparative systemic toxicity of methotrexate (MTX) with citrovorum factor rescue (CF), MTX alone and actinomycin-D (Act-D) in the treatment of gestational trophoblastic neoplasms (GTN) was evaluated in the present study. Treatment with MTX-CF was associated with only a 4% incidence (1 of 25 patients) of hepatic and/or hematologic toxicity and total absence of either a generalized rash or marked alopecia. In contrast, both MTX alone and Act-D were associated with a 48% incidence (12 of 25 patients) of hepatic and/or hematologic toxicity. Actinomycin-D also induced a generalized rash and marked alopecia in 24% (6 of 25 patients) and 52% (13 of 25 patients) of the patients respectively. We found that MTX-CF is the least toxic single agent chemotherapeutic regimen in the management of GTN.
AuthorsR S Berkowitz, D P Goldstein, M A Jones, A R Marean, M R Bernstein
JournalCancer (Cancer) Vol. 45 Issue 3 Pg. 423-6 (Feb 1980) ISSN: 0008-543X [Print] United States
PMID6243507 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Dactinomycin
  • Leucovorin
  • Methotrexate
Topics
  • Bone Marrow (drug effects)
  • Dactinomycin (adverse effects)
  • Drug Therapy, Combination
  • Female
  • Humans
  • Leucovorin (administration & dosage, adverse effects)
  • Liver (drug effects)
  • Methotrexate (administration & dosage, adverse effects)
  • Pregnancy
  • Trophoblastic Neoplasms (drug therapy)
  • Uterine Neoplasms (drug therapy)

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