Abstract |
The comparative systemic toxicity of methotrexate (MTX) with citrovorum factor rescue (CF), MTX alone and actinomycin-D (Act-D) in the treatment of gestational trophoblastic neoplasms (GTN) was evaluated in the present study. Treatment with MTX-CF was associated with only a 4% incidence (1 of 25 patients) of hepatic and/or hematologic toxicity and total absence of either a generalized rash or marked alopecia. In contrast, both MTX alone and Act-D were associated with a 48% incidence (12 of 25 patients) of hepatic and/or hematologic toxicity. Actinomycin-D also induced a generalized rash and marked alopecia in 24% (6 of 25 patients) and 52% (13 of 25 patients) of the patients respectively. We found that MTX-CF is the least toxic single agent chemotherapeutic regimen in the management of GTN.
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Authors | R S Berkowitz, D P Goldstein, M A Jones, A R Marean, M R Bernstein |
Journal | Cancer
(Cancer)
Vol. 45
Issue 3
Pg. 423-6
(Feb 1980)
ISSN: 0008-543X [Print] United States |
PMID | 6243507
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Dactinomycin
- Leucovorin
- Methotrexate
|
Topics |
- Bone Marrow
(drug effects)
- Dactinomycin
(adverse effects)
- Drug Therapy, Combination
- Female
- Humans
- Leucovorin
(administration & dosage, adverse effects)
- Liver
(drug effects)
- Methotrexate
(administration & dosage, adverse effects)
- Pregnancy
- Trophoblastic Neoplasms
(drug therapy)
- Uterine Neoplasms
(drug therapy)
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