[Effect of multiple injections of hepatic chalones on the multiplication of hepatoma 22a cells and the primary immune response in the body].

Abstract

The amount of dividing and DNA-synthesizing cells was investigated in 22a hepatoma after injection of hepatic chalones to mice every 6 hours. Chalones were proved to lower sharply these indices, 3-6 h later they reach minimal values and remain at the lower level during the whole period of the investigation (27 h). Despite a pronounced inhibitory effect in the proliferating cell population there is a tendency to rhythmic proliferative processes. After cessation of prolonged (8 days) injections of the preparation the level of cell proliferation restores only by the 48th h after the last injection and the lifetime of animals with the tumour becomes twice as long. The preparation used possesses no immune properties.

• Authors: V B Zakharov, V G Pukhal'skaia
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 6 Issue 2 Pg. 26-9 ( 1984) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Vliianie mnogokratnogo vvedeniia pechenochnykh keĭlonov na razmnozhenie kletok gepatomy 22a i pervichnyĭ immunnyĭ otvet organizma.
• PMID: 6239770 (Publication Type: English Abstract, Journal Article)

Chemical References

• Growth Inhibitors

Topics

• Animals
• Antibody Formation (drug effects)
• Antibody-Producing Cells (immunology)
• Cell Division (drug effects)
• Growth Inhibitors (administration & dosage, pharmacology)
• Immunization
• Liver (analysis)
• Liver Neoplasms, Experimental (immunology, pathology)
• Male
• Mice
• Mice, Inbred C3H
• Mice, Inbred CBA
• Organ Specificity
• Rats