[Treatment of renal colic with intravenous ketoprofen].

In view of the part played by renal prostaglandins in the mechanisms responsible for pain in renal colic, it was worth trying to find out whether nonsteroidal anti-inflammatory agents, which inhibit prostaglandin synthesis, have an analgesic effect of their own. In a double-blind trial the effects of ketoprofen 100 mg administered intravenously alone or associated with noramidopyrine were investigated in 62 patients divided at random into two equal groups. A rapid analgesic effect was observed with no significant difference between the groups. No severe side-effects were recorded. The double-blind method made it possible to confirm that ketoprofen administered alone relieved pain in 97% of the patients (with complete sedation in 45%) and acted within 5 minutes. Owing to their effectiveness and safety nonsteroidal anti-inflammatory drugs (especially ketoprofen) may be proposed as an alternative to conventional treatments of renal colic. But because of their activity they should not be prescribed until a firm diagnosis has been made. The cause of the colic should also be rapidly determined in order to treat it as well as the pain it produces.
AuthorsJ P Pourrat, J M Dueymes, J J Conte
JournalPresse meĢdicale (Paris, France : 1983) (Presse Med) Vol. 13 Issue 35 Pg. 2125-8 (Oct 6 1984) ISSN: 0755-4982 [Print] FRANCE
Vernacular TitleTraitement de la colique néphrétique par le kétoprofène intraveineux.
PMID6238315 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Phenylpropionates
  • Ketoprofen
  • Adult
  • Aged
  • Colic (drug therapy)
  • Double-Blind Method
  • Drug Evaluation
  • Emergencies
  • Female
  • Humans
  • Injections, Intravenous
  • Ketoprofen (administration & dosage, therapeutic use)
  • Kidney Diseases (drug therapy)
  • Male
  • Middle Aged
  • Phenylpropionates (therapeutic use)

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