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Estrogen receptor status, adrenal androgens and 7 alpha-hydroxydehydroepiandrosterone in breast cancer patients.

Abstract
Plasma concentrations of dehydroepiandrosterone (DHA), DHA-sulphate (DHAS) and 7 alpha hydroxy-DHA (7 alpha OHDHA) were measured and compared with tumor estrogen receptor (ER) status in 33 postmenopausal patients with breast cancer. Although the plasma concentrations of DHA, DHAS and 7 alpha OHDHA were not different between the ER-positive (ER+) and ER-negative (ER-) patient groups, the ratios of 7 alpha OHDHA/DHAS and of DHA/DHAS were significantly higher (P less than 0.001 and P less than 0.001 respectively) in the ER- group. Nine women (normal or with benign breast disease) of similar age and menopausal status had values for plasma 7 alpha OHDHA/DHAS and DHA/DHAS between those of ER+ and ER- patient groups. The measurement of these steroid ratios in the plasma of breast cancer patients thus provides an indirect estimate of ER status. Since DHA and 7 alpha OHDHA are major metabolites of precursor DHAS in mammary tumor tissues, changes in their relative quantities in plasma may reflect the influence of receptor-mediated events on mammary steroid metabolism. Alternatively, the relative increase in tumor metabolism of androgens inferred from high 7 alpha OHDHA/DHAS and DHA/DHAS ratios in the ER- group may disrupt the hormonal microenvironment of the estrogen receptor. These events may, in turn, predispose toward ER status and a poor response to endocrine therapy.
AuthorsS J Skinner, I M Holdaway, B H Mason, R A Couch, R G Kay
JournalEuropean journal of cancer & clinical oncology (Eur J Cancer Clin Oncol) Vol. 20 Issue 10 Pg. 1227-31 (Oct 1984) ISSN: 0277-5379 [Print] England
PMID6237915 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Estrogen
  • Dehydroepiandrosterone
  • 7-hydroxydehydroepiandrosterone
  • Dehydroepiandrosterone Sulfate
Topics
  • Age Factors
  • Aged
  • Breast Neoplasms (blood, metabolism)
  • Dehydroepiandrosterone (analogs & derivatives, blood)
  • Dehydroepiandrosterone Sulfate
  • Female
  • Humans
  • Menopause
  • Middle Aged
  • Receptors, Estrogen (metabolism)

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