Porokeratosis of Mibelli: benzylhydrochlorothiazide-induced new lesions accompanied by eosinophilic spongiosis.

Abstract

We observed the course of development of porokeratosis stimulated by benzylhydrochlorothiazide (BHCTh) in normal-appearing skin of a patient with long-standing stable porokeratosis of Mibelli. A 72-year-old Japanese man had had porokeratosis of Mibelli for more than 50 years. During administration of BHCTh for 1 year because of his hypertension, a lichenoid drug eruption developed over the lesions of porokeratosis on the flexor aspects of his legs. Readministration of BHCTh by another physician for 6 months resulted in the occurrence of a similar drug eruption that converted into typical skin lesions of porokeratosis 8 weeks later. Serial microscopic examination suggested that BHCTh administration resulted in eosinophilic spongiosis and cornoid lamella formation, which developed into epidermal changes characteristic of porokeratosis.

• Authors: N Inamoto, T Watanabe, K Nakamura
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 11 Issue 2 Pt 2 Pg. 357-61 (Aug 1984) ISSN: 0190-9622 [Print] United States
• PMID: 6237130 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hydrochlorothiazide
• benzylhydrochlorothiazide

Topics

• Aged
• Drug Eruptions (pathology)
• Eosinophilia (chemically induced, pathology)
• Humans
• Hydrochlorothiazide (adverse effects, analogs & derivatives, therapeutic use)
• Hypertension (drug therapy)
• Keratosis (chemically induced, pathology)
• Male
• Skin (pathology)