Effects of synthetic thymosin beta 9 fragments on low E-rosette-forming cells of lupus nephritis patients.

Abstract

Five fragments from hexapeptide to decapeptide, corresponding to positions 16-25 of thymosin beta 9, were synthesized and their effects on low E-rosette-forming capacity with sheep erythrocytes of cells from lupus nephritis patients were compared with that of the undecapeptide (positions 16-26) of thymosin beta 9 by taking synthetic thymosin beta 9 as a standard. Two of the fragments (16-25 and 18-25) exhibited higher activity than that of the parent peptide (16-26). The other three sequences (17-25, 19-25, and 20-25) had no effect at concentrations as high as 10(-4) M.

• Authors: T Abiko, H Sekino
• Journal: Journal of applied biochemistry (J Appl Biochem) Vol. 5 Issue 6 Pg. 446-52 (Dec 1983) ISSN: 0161-7354 [Print] United States
• PMID: 6236194 (Publication Type: Journal Article)

Chemical References

• Indicators and Reagents
• Peptide Fragments
• Thymosin
• thymosin beta(9)

Topics

• Amino Acid Sequence
• Glomerulonephritis (immunology)
• Humans
• Immune Complex Diseases (immunology)
• Indicators and Reagents
• Lupus Erythematosus, Systemic (immunology)
• Peptide Fragments (chemical synthesis, pharmacology)
• Rosette Formation
• Syndrome
• Thymosin (analogs & derivatives, chemical synthesis, pharmacology)