[Biological activity of epidermal chalones in the presence of blood serum from patients with psoriasis].

Abstract

The serum of patients with progressive psoriasis lessens the inhibitory activity of epidermal chalones if it is added to the cultural medium before chalones. On the contrary, chalones inhibit DNA synthesis in epithelial cells if they are added to the cultural medium before psoriatic serum. The blood serum of patients with stationary and regressive psoriasis does not exert any effect on chalone activity.

• Authors: N N Tret'iakova
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 97 Issue 6 Pg. 754-5 (Jun 1984) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Biologicheskaia aktivnost' épidermal'nykh keĭlonov v prisutstvii syvorotki krovi bol'nykh psoriazom.
• PMID: 6234950 (Publication Type: English Abstract, Journal Article)

Chemical References

• Growth Inhibitors
• DNA

Topics

• Adolescent
• Adult
• Animals
• DNA (biosynthesis)
• Epithelial Cells
• Epithelium (drug effects)
• Female
• Growth Inhibitors (pharmacology)
• Humans
• Male
• Middle Aged
• Psoriasis (blood)
• Rats