Abstract |
Norfloxacin, an orally administered quinoline carboxylic acid that is structurally related to nalidixic acid, has been shown to be highly active in vitro against penicillinase-producing Neisseria gonorrhoeae. Ninety-two men with culture-proved gonococcal urethritis, 46 per cent with penicillinase-producing N. gonorrhoeae, and 27 per cent with non- penicillinase-producing N. gonorrhoeae that was resistant to penicillin were given either 1200 mg of norfloxacin divided into two equal oral doses four hours apart (59 patients) or 2 g of spectinomycin intramuscularly (33 patients). All patients in both treatment groups were cured. No adverse reactions were reported in either group. We conclude that a two-dose, single-day regimen of orally administered norfloxacin is effective therapy for uncomplicated urethritis caused by penicillin-resistant strains of N. gonorrhoeae.
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Authors | S R Crider, S D Colby, L K Miller, W O Harrison, S B Kerbs, S W Berg |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 311
Issue 3
Pg. 137-40
(Jul 19 1984)
ISSN: 0028-4793 [Print] United States |
PMID | 6234465
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Anti-Bacterial Agents
- Penicillins
- Nalidixic Acid
- Spectinomycin
- Norfloxacin
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Topics |
- Administration, Oral
- Anti-Bacterial Agents
(administration & dosage, adverse effects, therapeutic use)
- Drug Tolerance
- Gonorrhea
(drug therapy, microbiology)
- Humans
- Male
- Nalidixic Acid
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Neisseria gonorrhoeae
(drug effects)
- Norfloxacin
- Penicillin Resistance
- Penicillins
(pharmacology)
- Spectinomycin
(therapeutic use)
- Urethritis
(drug therapy)
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