Abstract |
Skin lesions from 15 patients with mycosis fungoides (MF) and from three with parapsoriasis were studied immunohistochemically with monoclonal antibodies against T cells (Leu 1) and against T-cell subsets (Leu 2a, Leu 3a). Lymphoid cell reactivity was diverse among these sampled cases. In two cases of parapsoriasis and nine of MF, there was a predominance of helper/inducer (Leu-3a-reactive) cells over suppressor/cytotoxic (Leu-2a-reactive) cells. In one case of parapsoriasis and one (advanced tumor stage) of MF, there was suppressor/cytotoxic cell predominance. One case of MF showed strong reactivity for both T-cell subset markers. Four cases of MF (two plaque-stage and two tumor-stage) featured a predominant cell type in the dermis which was nonreactive for all three antibodies. The intraepidermal lymphoid cellularity was Leu-1-reactive in ten cases of MF and two of parapsoriasis. Among these 12 cases, the intraepidermal cellularity was Leu-2a-reactive in four and Leu-3a-reactive in three. The use of such studies of T-cell subsets on in situ cutaneous lymphoid infiltrates may demonstrate a correlation with cytomorphology, clinical stage, and disease prognosis.
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Authors | S A Buechner, R K Winkelmann, P M Banks |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 120
Issue 7
Pg. 897-905
(Jul 1984)
ISSN: 0003-987X [Print] United States |
PMID | 6233942
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Antigens, Surface
- HLA-DR Antigens
- Histocompatibility Antigens Class II
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Topics |
- Adult
- Aged
- Antibodies, Monoclonal
(immunology)
- Antigens, Surface
(analysis)
- Female
- HLA-DR Antigens
- Histocompatibility Antigens Class II
(analysis)
- Histocytochemistry
- Humans
- Male
- Middle Aged
- Mycoses
(immunology, pathology)
- Parapsoriasis
(immunology, pathology)
- Skin
(pathology)
- T-Lymphocytes
(immunology)
- T-Lymphocytes, Helper-Inducer
(immunology)
- T-Lymphocytes, Regulatory
(immunology)
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