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High-dose cytosine arabinoside and m-AMSA is effective therapy in relapsed acute nonlymphocytic leukemia.

Abstract
High-dose cytosine arabinoside ( HDARAC ) and 4'-(9 acridinylamino) methane sulfon -m-anisidine (m-AMSA) was administered as induction therapy to 40 patients with relapsed or refractory acute nonlymphocytic leukemia (ANLL) with the following results: 28 patients (70%) achieved complete remission, one patient achieved a partial remission; five patients died with hypoplastic bone marrows containing less than 5% blasts; four patients died with hypoplastic marrowing containing greater than 5% blasts; and three patients failed to achieve marrow aplasia and died without significant cytoreduction in percentage of blasts. Consolidation therapy was not used and maintenance therapy was given to less than 10% (three patients) of remission patients. The median duration of remission for all patients was 6.0 months and the median time for the complete remission patients exceeded eight months. This regimen has acceptable toxicity and the results are equivalent to those obtained from conventional induction therapy of de novo ANLL patients.
AuthorsJ D Hines, M M Oken, J J Mazza, A M Keller, R R Streeter, J H Glick
JournalJournal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 2 Issue 6 Pg. 545-9 (Jun 1984) ISSN: 0732-183X [Print] United States
PMID6233399 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Aminoacridines
  • Amsacrine
  • Cytarabine
Topics
  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Aminoacridines (administration & dosage, adverse effects)
  • Amsacrine
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
  • Bone Marrow (drug effects)
  • Cytarabine (administration & dosage, adverse effects)
  • Drug Eruptions (etiology)
  • Hemorrhage (chemically induced)
  • Humans
  • Leukemia (drug therapy, mortality)
  • Middle Aged
  • Nausea (chemically induced)
  • Recurrence
  • Vomiting

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