Skin irritation by dithranol (anthralin) and its 10-acyl analogues in 3 animal models.

Abstract

The skin irritant properties of a single application of dithranol (anthralin), a typical "delayed irritant", and its 10-acyl analogues in acetone or white petrolatum were compared in 3 animals models. Maximal irritation was reached at about 24 h in mouse ear, 48 h in guinea pig back and 1 week in miniature swine back, the last-mentioned serving as a good model of human skin. In all animal species, butantrone was significantly less irritant than dithranol, 10-acetyl dithranol or 10-propionyl dithranol. 10-acetyl dithranol was the most irritant compound. Clinical trials with butantrone on psoriasis are justified.

• Authors: P Männistö, A Havas, K Haasio, H Hanhijärvi, K Mustakallio
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 10 Issue 3 Pg. 140-5 (Mar 1984) ISSN: 0105-1873 [Print] England
• PMID: 6232099 (Publication Type: Journal Article)

Chemical References

• Anthracenes
• butantrone
• Anthralin

Topics

• Animals
• Anthracenes (toxicity)
• Anthralin (analogs & derivatives, toxicity)
• Dose-Response Relationship, Drug
• Drug Eruptions (etiology)
• Female
• Guinea Pigs
• Male
• Mice
• Swine
• Swine, Miniature