Nicorandil attenuates myocardial acidosis during coronary occlusion in dogs.

Abstract

In dogs anaesthetized with pentobarbitone, the left anterior descending coronary artery (LAD) was partially occluded. Before and 30 min after partial occlusion, the myocardial pH was 7.52-7.54 and 6.89-6.91, respectively. Nicorandil (50 micrograms kg-1, i.v.) increased the pH that had been reduced by partial occlusion and this effect lasted at least 60 min. Thus nicorandil attenuates ischaemic myocardial acidosis.

• Authors: Y Abiko, T Nishimura, K Sakai
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 81 Issue 2 Pg. 409-11 (Feb 1984) ISSN: 0007-1188 [Print] England
• PMID: 6231074 (Publication Type: Journal Article)

Chemical References

• Vasodilator Agents
• Niacinamide
• Nicorandil

Topics

• Acidosis (drug therapy, etiology, metabolism)
• Animals
• Coronary Disease (complications, drug therapy, metabolism)
• Dogs
• Female
• Heart Diseases (drug therapy, etiology, metabolism)
• Male
• Niacinamide (analogs & derivatives, therapeutic use)
• Nicorandil
• Vasodilator Agents (therapeutic use)