Abstract |
5-FU analogs being investigated in Japan are; 5-FU, FT, FD-1, HCFU, UFT, TAC-278, 5'-DFUR, FF-705, and TK-117. They exert antitumor activity via 5-FU which is an intermediate metabolite of those derivatives. In this paper, UFT, TAC-278, and 5'-DFUR, were particularly investigated from the point of view of pharmacokinetics of those drugs (or 5-FU) in the blood, normal and tumor tissues of patients with gastric cancer. As a result, it is concluded that observation of the sequential changes of 5-FU level in various tissues of humans is potential in designing cancer chemotherapy.
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Authors | K Kimura, S Suga |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 9
Issue 8
Pg. 1321-6
(Aug 1982)
ISSN: 0385-0684 [Print] Japan |
PMID | 6223594
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Drug Combinations
- Floxuridine
- Tegafur
- Uracil
- TAC 278
- Fluorouracil
- doxifluridine
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
- Drug Combinations
(metabolism)
- Floxuridine
(metabolism)
- Fluorouracil
(analogs & derivatives, metabolism)
- Humans
- Kinetics
- Neoplasms
(metabolism)
- Tegafur
(metabolism)
- Uracil
(metabolism)
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