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[Pharmacological and pharmacodynamic aspects of cancer chemotherapy, with special reference to 5-fluorouracil and its derivatives].

Abstract
5-FU analogs being investigated in Japan are; 5-FU, FT, FD-1, HCFU, UFT, TAC-278, 5'-DFUR, FF-705, and TK-117. They exert antitumor activity via 5-FU which is an intermediate metabolite of those derivatives. In this paper, UFT, TAC-278, and 5'-DFUR, were particularly investigated from the point of view of pharmacokinetics of those drugs (or 5-FU) in the blood, normal and tumor tissues of patients with gastric cancer. As a result, it is concluded that observation of the sequential changes of 5-FU level in various tissues of humans is potential in designing cancer chemotherapy.
AuthorsK Kimura, S Suga
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 9 Issue 8 Pg. 1321-6 (Aug 1982) ISSN: 0385-0684 [Print] Japan
PMID6223594 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Drug Combinations
  • Floxuridine
  • Tegafur
  • Uracil
  • TAC 278
  • Fluorouracil
  • doxifluridine
Topics
  • Antineoplastic Combined Chemotherapy Protocols
  • Drug Combinations (metabolism)
  • Floxuridine (metabolism)
  • Fluorouracil (analogs & derivatives, metabolism)
  • Humans
  • Kinetics
  • Neoplasms (metabolism)
  • Tegafur (metabolism)
  • Uracil (metabolism)

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