Contact allergy to trimethylolpropane triacrylate (TMPTA) in an aziridine plastic hardener.

Abstract

4 workers developed hand and face dermatitis when exposed to a floor top coat. This contained a polyurethane and a polyfunctional aziridine hardener and additives. The aziridine hardener was made by reacting propyleneimine with a polyfunctional acrylate, trimethylolpropane triacrylate (TMPTA). All 4 reacted to the hardener and to TMPTA, which is present in excess. 2 of them also reacted to pentaerythritol triacrylate (PETA), which can be used in the production of aziridine hardeners. TMPTA and PETA cross-react, and are known sensitizers in UV-hardening acrylates. The present finding shows that well-known sensitizers can be found in hidden sources when used in a quite different chemical process.

• Authors: I Dahlquist, S Fregert, L Trulson
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 9 Issue 2 Pg. 122-4 (Mar 1983) ISSN: 0105-1873 [Print] England
• PMID: 6221863 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acrylates
• trimethylolpropane triacrylate

Topics

• Acrylates (adverse effects)
• Chemical Phenomena
• Chemistry
• Dermatitis, Contact (etiology)
• Dermatitis, Occupational (etiology)
• Hand Dermatoses (etiology)
• Humans
• Patch Tests