[Effects of 5023 SE on experimental cerebral ischemia in gerbils].

Abstract

Unilateral ligation of the common carotid artery of gerbils results in cerebral edema and ipsilateral hemiparesia ending in death. The clinical symptoms of this experimental ischaemia can be quantified. Comparison of untreated gerbils and gerbils treated with Duxil showed that the drug reduces the neuropathological symptoms and cerebral edema induced by ischaemia and improves the vital prognosis in these animals.

• Authors: J Duhault, F Roman, O Dellazuana, H Actis
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 12 Issue 13 Pg. 844-6 (Mar 24 1983) ISSN: 0755-4982 [Print] France
• Vernacular Title: Effets du 5023 SE sur l'ischémie cérébrale expérimentale chez la gerbille.
• PMID: 6220333 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Piperazines
• Yohimbine
• almitrine, raubasine drug combination
• Almitrine

Topics

• Almitrine
• Animals
• Brain Ischemia (drug therapy)
• Disease Models, Animal
• Drug Combinations (therapeutic use)
• Gerbillinae
• Piperazines (therapeutic use)
• Time Factors
• Yohimbine (therapeutic use)