Suppression of unprimed T and B cells in antibody responses by irradiation-resistant and plastic-adherent suppressor cells in Toxoplasma gondii-infected mice.

Abstract

In the acute phase of Toxoplasma infection, the function of both helper T and B cells was suppressed in primary antibody responses to dinitrophenol (DNP)-conjugated protein antigens. During the course of infection, the suppressive effect on T cells seems to continue longer than that on B cells, since suppression in responses to sheep erythrocytes, a T-dependent antigen, persisted longer than those to DNP-Ficoll, a T-independent antigen. Plastic-adherent cells from the spleens of Toxoplasma-infected and X-irradiated (400 rads) mice had strong suppressor activity in primary anti-sheep erythrocyte antibody responses of normal mouse spleen cells in vitro. These data suggest that the activation of irradiation-resistant and plastic-adherent suppressor cells causes the suppression of both T and B cells in Toxoplasma-infected mice.

• Authors: Y Suzuki, A Kobayashi
• Journal: Infection and immunity (Infect Immun) Vol. 40 Issue 1 Pg. 1-7 (Apr 1983) ISSN: 0019-9567 [Print] United States
• PMID: 6219954 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNP-Ficoll
• Immunoglobulin G
• Isoantibodies
• Ficoll
• Immunoglobulin E

Topics

• Animals
• Antibody Formation (radiation effects)
• B-Lymphocytes (immunology)
• Cell Adhesion
• Female
• Ficoll (analogs & derivatives, immunology)
• Hemagglutination Tests
• Immunization, Passive
• Immunoglobulin E (biosynthesis)
• Immunoglobulin G (biosynthesis)
• Isoantibodies (biosynthesis)
• Mice
• Mice, Inbred C57BL
• Phagocytosis
• Rats
• Rats, Inbred Strains
• T-Lymphocytes (immunology)
• T-Lymphocytes, Regulatory (enzymology, immunology, radiation effects)
• Toxoplasmosis, Animal (immunology)