Moxalactam therapy for gram-negative bacillary meningitis.

Abstract

Twenty patients with gram-negative bacillary meningitis (19 episodes caused by enteric bacilli and one by Pseudomonas aeruginosa) were treated with moxalactam given intravenously. Seventeen patients responded well clinically and bacteriologically without known relapse. Fourteen of 18 isolates from cerebrospinal fluid were susceptible to less than or equal to 0.5 micrograms of moxalactam/ml. Cerebrospinal fluid concentrations of moxalactam in four patients were 2.4-16 micrograms/ml. This accumulated experience indicates that moxalactam has been effective in the treatment of patients with meningitis due to highly susceptible enteric gram-negative bacilli. However, it cannot be recommended as single-drug therapy for meningitis due to P. aeruginosa or Acinetobacter.

• Authors: J J Rahal Jr
• Journal: Reviews of infectious diseases (Rev Infect Dis) 1982 Nov-Dec Vol. 4 Suppl Pg. S606-9 ISSN: 0162-0886 [Print] United States
• PMID: 6218572 (Publication Type: Journal Article)

Chemical References

• Cephalosporins
• Cephamycins
• Moxalactam

Topics

• Adolescent
• Adult
• Aged
• Cephalosporins (therapeutic use)
• Cephamycins (adverse effects, therapeutic use)
• Child
• Child, Preschool
• Enterobacteriaceae Infections (drug therapy)
• Humans
• Infant
• Meningitis (cerebrospinal fluid, drug therapy, microbiology)
• Middle Aged
• Moxalactam
• Pseudomonas Infections (drug therapy)