[Antibiotic concentrations in the abdominal cavity as basis for antibacterial therapy of peritonitis: penetration of mezlocillin into the peritoneal exudate].

Abstract

The importance of the antibiotic concentration in peritoneal exudate is emphasized as a criterium for the possible success of antibiotic therapy of intra-abdominal infections. 5 g of mezlocillin were given i. v. over 15 min to ten patients with a mean age of 56 years. The serum concentrations, assayed microbiologically, were: 299.5 mg/l at the end of the infusion, 103.2 mg/l, 18.6 mg/l and 2.1 mg/l 60, 240 and 480 min after the end of the infusion, respectively. The serum half-life T1/2 beta, calculated from the beta phase, was 67 min. In the peritoneal fluid the peak concentration of Cp = 42.0 mg/l was achieved after 2.2 h. A quarter of this concentration was maintained in the peritoneal cavity for five to six hours. This concentration inhibited 74% of the 322 pathogens isolated from 123 intra-abdominal infections.

• Authors: D H Wittmann, J Welter, H H Schassan
• Journal: Infection (Infection) Vol. 10 Suppl 3 Pg. S204-8 ( 1982) ISSN: 0300-8126 [Print] Germany
• Vernacular Title: Antibiotikakonzentrationen in der Bauchhöhle als Grundlage der antibakteriellen Peritonitistherapie: Zur Frage der Penetration von Mezlocillin in das Peritonealexsudat.
• PMID: 6218115 (Publication Type: English Abstract, Journal Article)

Chemical References

• Penicillins
• Mezlocillin

Topics

• Ascitic Fluid (analysis, metabolism)
• Humans
• Kinetics
• Mezlocillin
• Middle Aged
• Penicillins (analysis, blood, metabolism)
• Peritonitis (drug therapy, surgery)
• Postoperative Period