[Effect of the administration of estrogen-antiestrogen combinations on the experimental infection of the hamster with Schistosoma mansoni].

Abstract

In the purpose of establishing if the antiestrogens may inhib the protective effects of the estrogens during an experimental infection with Schistosoma mansoni in golden female hamster, we have studied the following estrogen-anti-estrogen associations: 17 beta-estradiol + trans-tamoxifène, 17 beta-estradiol + trans-clomifène, hexestrol + trans-tamoxifène. The decrease of the number of worms in the animals under experiment shows that these associations still give a protective effect. This protection is however weaker than the one which is induced by estrogens administration only. The interpretation of these results agree with the intervention of an estrogen receptor.

• Authors: A Barrabes, T H Duong, R Lacroix, C Combescot
• Journal: Comptes rendus des seances de la Societe de biologie et de ses filiales (C R Seances Soc Biol Fil) Vol. 176 Issue 3 Pg. 283-7 ( 1982) ISSN: 0037-9026 [Print] France
• Vernacular Title: Influence de l'administration d'associations estrogène-antiestrogène sur la parasitose expérimentale à Schistosoma mansoni du hamster.
• PMID: 6215092 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Estrogen Antagonists
• Estrogens
• Receptors, Estrogen

Topics

• Animals
• Cricetinae
• Drug Combinations
• Estrogen Antagonists (administration & dosage)
• Estrogens (administration & dosage)
• Female
• Mesocricetus
• Receptors, Estrogen (physiology)
• Schistosoma mansoni
• Schistosomiasis (physiopathology)