Abstract |
In adult rats an anterodorsal bilateral hippocampectomy produced an increase in motor activity without modification of the amount of the different sleep stages. In hippocampectomized rats p-chlorophenylalanine produced an insomnia which can be reversed by 5-HTP. These results show that the insomnia produced by brain serotonin depletion is not a result of the hyperactivity produced by the treatments which cause such depletion.
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Authors | R F Laguzzi |
Journal | Brain research
(Brain Res)
Vol. 240
Issue 1
Pg. 175-7
(May 20 1982)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 6212096
(Publication Type: Journal Article)
|
Chemical References |
- Serotonin Antagonists
- Serotonin
- Fenclonine
|
Topics |
- Animals
- Dose-Response Relationship, Drug
- Fenclonine
(pharmacology)
- Hippocampus
(physiology)
- Male
- Rats
- Serotonin
(biosynthesis)
- Serotonin Antagonists
- Sleep
(drug effects, physiology)
- Sleep, REM
(drug effects)
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