Inferior olivary neurons: 3-acetylpyridine effects on glucose consumption, axonal transport, electrical activity and harmaline-induced tremor.

Abstract

The effects of 3-acetylpyridine (3-AP) on the neurons in the inferior olive (IO) were studied by several methods to establish the time-order of events due to the neurotoxicity of 3-AP in the rat. It was found that IO metabolism, studied with [14C]2-deoxyglucose, began to decrease detectably 1 h after 3-AP and was totally suppressed at 3 h. Retrograde axonal transport of lectin horseradish peroxidase (HRP) from cerebellar cortex to the IO was also totally suppressed 3 h after 3-AP and in fact showed a time course similar to that for the suppression of metabolism. Harmaline produced tremor has been shown to induce rhythmic activity and increase glucose consumption in the IO. When injected in 3-AP treated animals, harmaline produced its usual effects at 2 h after the 3-AP but had no effects after 3 h. The present results indicate that the neurotoxic effects of 3-AP are not simply graded in time, but tend to have the greatest effects between the 2nd and 3rd hour following its administration.

• Authors: J F Bernard, C Buisseret-Delmas, S Laplante
• Journal: Brain research (Brain Res) Vol. 322 Issue 2 Pg. 382-7 (Nov 26 1984) ISSN: 0006-8993 [Print] Netherlands
• PMID: 6210132 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Pyridines
• 3-acetylpyridine
• Deoxyglucose
• Harmaline
• Glucose

Topics

• Alkaloids (antagonists & inhibitors)
• Animals
• Autoradiography
• Axonal Transport (drug effects)
• Deoxyglucose (metabolism)
• Glucose (metabolism)
• Harmaline (antagonists & inhibitors)
• Olivary Nucleus (drug effects, metabolism)
• Pyridines (pharmacology)
• Rats
• Tremor (chemically induced)