The effect of the stable prostacyclin analogue ZK 36374 on experimental coronary thrombosis in the pig.

Abstract

The hemodynamic and antithrombotic action of ZK 36374, a stable carbacyclin derivative of prostacyclin, was studied during electrically-induced coronary artery thrombosis in the open chest anesthetized pig. Infusion of ZK 36374 (100 ng/kg/min, n = 6) had no effect on heart rate and cardiac output, but caused a 20% reduction in mean arterial blood pressure by peripheral vasodilation. In animals receiving solvent or no drug prior to thrombosis induction, the time to occlusive coronary artery thrombosis (TOT) was 30 +/- 2 minutes (mean +/- SEM, n = 17). Pretreatment with an i.v. infusion of ZK 36374 (100 ng/kg/min) prolonged TOT by 50% to 47 +/- 7 minutes (p less than 0.005, n = 6). This prolongation of TOT was not due to the lower blood pressure in the ZK 36374 group, as dihydralazine in a dose that lowered arterial blood pressure to the same extent had no effect on TOT (32 +/- 4 minutes, n = 4). The results indicate that ZK 36374 may be useful in delaying (or preventing) occlusive coronary artery thrombi.

• Authors: W J van der Giessen, W J Mooi, A M Rutteman, L Berk, P D Verdouw
• Journal: Thrombosis research (Thromb Res) Vol. 36 Issue 1 Pg. 45-51 (Oct 01 1984) ISSN: 0049-3848 [Print] United States
• PMID: 6209820 (Publication Type: Journal Article)

Chemical References

• Cardiotonic Agents
• Fibrinolytic Agents
• Epoprostenol
• Iloprost

Topics

• Animals
• Arterial Occlusive Diseases (physiopathology)
• Cardiotonic Agents (pharmacology)
• Coronary Disease (blood, drug therapy, physiopathology)
• Disease Models, Animal
• Epoprostenol (pharmacology)
• Fibrinolytic Agents (pharmacology)
• Hemodynamics (drug effects)
• Iloprost
• Platelet Aggregation (drug effects)
• Swine