HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Paradoxical effects of interferon on reactivation of oral infection with herpes simplex virus after microvascular decompression for trigeminal neuralgia.

Abstract
Fifty-five patients undergoing microvascular decompression for trigeminal neuralgia were divided into three groups in a two-stage placebo-controlled study. All groups received two injections a day for five days beginning the day before surgery. Twenty-one patients received 10 placebo injections, 11 in the presurgical treatment group received three injections of 3.5 X 10(4) units of leukocyte interferon/kg before surgery, and 23 in the postsurgical treatment group received seven injections after surgery. The remaining injections in the two treatment groups were placebos. In the first stage, with 30 patients, 91% of the presurgical treatment group had reactivated oral herpesvirus infections (manifested by herpetic lesions and/or oral viral shedding) significantly more often than did concurrent controls (P less than .05). In the second stage, only the postsurgical treatment and placebo groups were studied, with no difference in reactivation of herpesvirus infection between the postsurgical treatment and placebo groups. Thus presurgical treatment with interferon alone may actually precipitate and accentuate herpesvirus infection.
AuthorsM Ho, G J Pazin, J A Armstrong, H S Haverkos, J S Dummer, P J Jannetta
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 150 Issue 6 Pg. 867-72 (Dec 1984) ISSN: 0022-1899 [Print] United States
PMID6209346 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Interferons
Topics
  • Adult
  • Aged
  • Female
  • Herpes Labialis (etiology, prevention & control)
  • Humans
  • Interferons (therapeutic use)
  • Male
  • Middle Aged
  • Postoperative Complications (therapy)
  • Recurrence
  • Trigeminal Neuralgia (surgery)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: