[Comparative study of the efficacy of the DBVCy protocol (daunoblastin, bleomycin, vincristine, cytostasan) and the ABVD protocol in advanced Hodgkin's lymphoma. A prospective inter-clinic study within the framework of the Hauptforschungsrichtung Geschwulsterkrankungen].

Abstract

In MOPP-resistant patients with Hodgkin-lymphoma stage III B and IV the well known ABVD-protocol was compared with the DBVCy-protocol (daunorubicin, bleomycin, vincristine, cytostasan) in a randomized prospective trial. 73 patients were evaluable, 35 received ABVD, 38 DBVCy. 4 out of 35 (11%) in the ABVD-group and 9 out of 38(24%) in the DBVCy-group reached complete remission. The median duration of the remission for DBVCy was 4,5 months, for ABVD 3,4 months (no significance). Median survivals (61 months in DBVCy and 37 months in ABVD) did not show significant differences; but the DBVCy-scheme seems to be better tolerabel. With the given evaluation can not be proved a difference between the two groups, but it is not likely, that one of the regimen is very much better or very much worse as the other.

• Authors: D Höche, K Wutke, G Anger, M Herold, R Kästner, H Stobbe, R Ihle, J Andres, C Raderecht, A Schleusner
• Journal: Archiv fur Geschwulstforschung (Arch Geschwulstforsch) Vol. 54 Issue 4 Pg. 333-42 ( 1984) ISSN: 0003-911X [Print] Germany
• Vernacular Title: Vergleichende Untersuchung zur Wirksamkeit des DBVCy-Protokolls (Daunoblastin, Bleomycin, Vincristin, Cytostasan) mit dem ABVD-Protokoll beim fortgeschrittenen Hodgkin-Lymphom. Eine prospektive interklinische Studie im Rahmen der Hauptforschungsrichtung Geschwulsterkrankungen.
• PMID: 6208874 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Nitrogen Mustard Compounds
• Bleomycin
• Vincristine
• Vinblastine
• Dacarbazine
• Doxorubicin
• Daunorubicin

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Bleomycin (administration & dosage, adverse effects)
• Clinical Trials as Topic
• Dacarbazine (administration & dosage, adverse effects)
• Daunorubicin (administration & dosage, adverse effects)
• Doxorubicin (administration & dosage, adverse effects)
• Female
• Hodgkin Disease (drug therapy)
• Humans
• Male
• Nitrogen Mustard Compounds (administration & dosage, adverse effects)
• Prospective Studies
• Random Allocation
• Vinblastine
• Vincristine (administration & dosage, adverse effects)