Phenotypic characterization of skin-infiltrating cells in pagetoid reticulosis by monoclonal antibodies.

Abstract

The immunological characterization of the infiltrating cells in a patient with a disseminated form of Pagetoid reticulosis (PR) was carried out-in histological section and cell suspensions--by means of a panel of monoclonal antibodies and classical markers (E-rosette and surface immunoglobulins (SIg]. Most of the infiltrating cells were seen to be mature T-lymphocytes with a suppressor/cytotoxic phenotype (T11+, T3+, T8+, T4-). The results suggest that this variant of PR represents a special histological type of cutaneous T cell lymphoma.

• Authors: M Gonzalez, M Martin-Pascual, J San Miguel, M D Caballero, A López Borrasca
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 64 Issue 5 Pg. 421-4 ( 1984) ISSN: 0001-5555 [Print] Sweden
• PMID: 6208722 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal

Topics

• Aged
• Antibodies, Monoclonal
• Female
• Humans
• Lymphatic Diseases (immunology, pathology)
• Lymphoma (immunology)
• Paget Disease, Extramammary (immunology, pathology)
• Phenotype
• Skin (cytology)
• Skin Neoplasms (immunology, pathology)
• T-Lymphocytes (classification, pathology)