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The pharmacology of endorphin modulation of chick distress vocalization.

Abstract
Intraventricular injections of beta-endorphin, gamma-endorphin and alpha-endorphin were demonstrated to reduce isolation-induced distress vocalization on 2-4 day old chicks in a dose response manner at doses as small as 12.5 picomoles (pmol). beta-Endorphin was more potent than the other peptides and morphine, while Met-enkephalin was without effect. However, the D-Ala2 substituted form of Met-enkephalin was as potent as morphine. None of the opioid peptides was effective when injected peripherally in doses of 400 pmol/g body weight. Extension of the interval between injection and behavioral observation from 4 minutes eliminated the ability of alpha- and gamma-endorphin to reduce the peeps. Specificity of the opioid effect was determined by testing intraventricular injections (200 pmol) of 9 other endogenously found peptides. Somatostatin, vasoactive intestinal peptide, and human pancreatic peptide reduced the vocalizations modestly, while alpha-MSH reliably increased them.
AuthorsT R Vilberg, J Panksepp, A J Kastin, D H Coy
JournalPeptides (Peptides) 1984 Jul-Aug Vol. 5 Issue 4 Pg. 823-7 ISSN: 0196-9781 [Print] United States
PMID6208536 (Publication Type: Journal Article)
Chemical References
  • Endorphins
  • Enkephalin, Methionine
  • beta-Endorphin
  • alpha-Endorphin
  • gamma-Endorphin
  • Morphine
Topics
  • Animals
  • Anxiety (physiopathology)
  • Cerebral Ventricles (drug effects)
  • Dose-Response Relationship, Drug
  • Endorphins (administration & dosage, pharmacology)
  • Enkephalin, Methionine (pharmacology)
  • Humans
  • Injections, Intraventricular
  • Male
  • Morphine (pharmacology)
  • Vocalization, Animal (drug effects)
  • alpha-Endorphin
  • beta-Endorphin
  • gamma-Endorphin

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