[Intravesical chemotherapy for superficial bladder tumors].

Abstract

Intravesical chemotherapy is one of the most effective treatments for superficial bladder tumors. Recent progress in the development of chemotherapeutic agents has provided a variety of compounds of potential benefit for intravesical administration in cases of superficial bladder tumors, including thio-TEPA, MMC, carboquone, adriamycin, FT-207, cytosine arabinoside and bleomycin, and the in therapeutic effectiveness has been reported. We selected adriamycin, because it is considered suitable for intravesical instillation. A 68% effectiveness has been experienced for instillation repeated six to nine times (adriamycin 50 mg/normal saline 30 ml) and side effects occurred in 23% of patients. Intravesical chemotherapy has also been attempted to prevent recurrence after conservative therapy but these modalities still seem to need further study.

• Authors: H Ohmori
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 11 Issue 8 Pg. 1557-62 (Aug 1984) ISSN: 0385-0684 [Print] Japan
• PMID: 6206797 (Publication Type: English Abstract, Journal Article)

Chemical References

• Mitomycins
• Cytarabine
• Bleomycin
• Tegafur
• Carbazilquinone
• Mitomycin
• Doxorubicin
• Thiotepa

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Carbazilquinone (administration & dosage)
• Cytarabine (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Administration Schedule
• Female
• Humans
• Male
• Mitomycin
• Mitomycins (administration & dosage)
• Tegafur (administration & dosage)
• Thiotepa (administration & dosage)
• Urinary Bladder
• Urinary Bladder Neoplasms (drug therapy)