Daunomycin-arachidonic acid complex as a potential new antitumor agent.

Abstract

A daunomycin-arachidonic acid complex (DM-C20:4) administered IV had a marked antitumor effect on the intraperitoneal growth of the AFP-producing hepatoma cell line, AH66. However, the daunomycin-arachidic acid (DM-C20:0) saturated fatty acid complex showed only the same antitumor effect on the AH66 cells as free daunomycin. It was demonstrated that the DM-C20:4 preparation maintained its chemical properties for some time in both plasma and liver homogenate.

• Authors: T Sasaki, Y Tsukada, H F Deutsch, H Hirai
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 13 Issue 2 Pg. 75-7 ( 1984) ISSN: 0344-5704 [Print] Germany
• PMID: 6205782 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Arachidonic Acids
• alpha-Fetoproteins
• daunomycin-arachidonic acid complex
• Daunorubicin

Topics

• Animals
• Arachidonic Acids (metabolism, therapeutic use)
• Daunorubicin (administration & dosage, analogs & derivatives, metabolism, therapeutic use)
• Liver Neoplasms, Experimental (drug therapy)
• Rats
• alpha-Fetoproteins (administration & dosage)