| Abstract | Myeloma IgE, obtained from ascitic fluid of rats previously inoculated with the IgE-producing cell line IR-162, was administered in prophylactic and therapeutic regimens to rats passively and actively sensitized to ovalbumin. Administration of myeloma IgE prior to passive sensitization resulted in approximately 95% inhibition of anaphylactic histamine release and significant protection from anaphylactic pulmonary distress. Myeloma IgE treatment prior and subsequent to active sensitization brought about a 70-80% inhibition of anaphylactic histamine release. A similar pattern of protection was seen in animals that received 5 but not 3 weekly myeloma IgE treatments subsequent to active sensitization. These findings indicate that treatment with nonspecific IgE prior to sensitization is effective in blocking anaphylactic reactions but competition with cell-bound IgE in sensitized animals requires prolonged administration of relatively large quantities of 'nonsense' IgE. |
| Authors | G M Butchko, R L Aspinall, W G Smith |
| Journal | International archives of allergy and applied immunology
(Int Arch Allergy Appl Immunol)
Vol. 75
Issue 1
Pg. 27-31
( 1984)
ISSN: 0020-5915 SWITZERLAND |
| PMID | 6204946
(Publication Type: Journal Article)
|
| Chemical References |
- Receptors, Immunologic
- Immunoglobulin E
|
| Topics |
- Anaphylaxis
- Animals
- Antibody Specificity
- Cell Line
- Histamine Release
- Immunization, Passive
- Immunoglobulin E
(pharmacology)
- Rats
- Receptors, Immunologic
(physiology)
- Respiratory Hypersensitivity
(immunology)
|
