Expression of HLA-DR (Ia like) antigen on epidermal keratinocytes in human dermatoses.

Abstract

Ia antigen (HLA-DR in man) has been demonstrated in keratinocytes in graft versus host disease. This study investigates the occurrence of HLA-DR in keratinocytes in the following dermatoses: eczematous dermatitis, discoid lupus erythematosus, with immunoglobulin and non-exposed skin from cases of systemic lupus erythematosus with immunoglobulin deposits, lichen planus, lichen simplex, bullous pemphigoid, pemphigus vulgaris, 'toxic erthema', tuberculid and chillblain. Keratinocyte staining was found in a variety of conditions. The unifying features of the instances of its occurrence was lymphoid infiltration and usually some focal evidence of keratinocyte damage. Thus in eczema the staining was mid-epidermal, while in discoid lupus erythematosus and lichen planus it was basal. HLA-DR staining was absent in bullous pemphigoid and pemphigus vulgaris, which is consistent with the hypothesis that in these conditions the damage is mediated by autoantibodies and complement in the absence of cellular immune attack.

• Authors: I A Lampert
• Journal: Clinical and experimental immunology (Clin Exp Immunol) Vol. 57 Issue 1 Pg. 93-100 (Jul 1984) ISSN: 0009-9104 [Print] England
• PMID: 6204802 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DR Antigens
• Histocompatibility Antigens Class II
• Keratins

Topics

• HLA-DR Antigens
• Histocompatibility Antigens Class II (analysis)
• Humans
• Immunity, Cellular
• Keratins
• Palatine Tonsil (immunology)
• Skin (immunology, pathology)
• Skin Diseases (immunology, pathology)