Multivariate analysis of risk factors in patients with metastatic testicular germ cell tumors treated with vinblastine and bleomycin.

Abstract

39 patients with testicular germ cell tumor metastases were treated with vinblastine intravenous bolus injection day 1 and day 36 and bleomycin intramuscularly twice weekly for 10 weeks. 8 patients had complete remission. 4 of these are alive with no evidence of disease for 91 + to 109 + months. Studied with Wilk's method for stepwise discriminant analysis tumor volume and performance status significantly predicted the patients who had complete remission. Studied with Cox's proportional hazard model for multivariate analysis hCG in the primary tumor, serum lactate dehydrogenase, performance status, and complete remission had a significant impact on survival. The information from the risk factors may be useful in a differentiated treatment of patients with testicular germ cell tumor metastases.

• Authors: F E von Eyben, G K Jacobsen, H Pedersen, M Jacobsen, P P Clausen, P C Zibrandtsen, B Gullberg
• Journal: Invasion & metastasis (Invasion Metastasis) Vol. 2 Issue 2 Pg. 125-35 ( 1982) ISSN: 0251-1789 [Print] Switzerland
• PMID: 6203868 (Publication Type: Journal Article)

Chemical References

• Bleomycin
• Vinblastine

Topics

• Actuarial Analysis
• Adolescent
• Adult
• Aged
• Analysis of Variance
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Histocytochemistry
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Neoplasm Staging
• Neoplasms, Germ Cell and Embryonal (drug therapy, mortality, secondary)
• Prognosis
• Testicular Neoplasms (drug therapy, mortality)
• Vinblastine (administration & dosage)