HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Plasma beta-thromboglobulin, platelet factor 4, fibrinopeptide A, and other hemostatic functions during improved, short-term glycemic control in diabetes mellitus.

Abstract
To determine the effect of improved, short-term glycemic control on various functions of hemostasis in insulin-dependent diabetes, we measured changes in plasma fibrinogen, fibrinopeptide A (FPA), functional antithrombin III (AT-III), factor VIII:ristocetin cofactor ( VIIIRCoF ), beta-thromboglobulin (BTG), platelet factor 4 (PF4), and platelet aggregation responses to ADP and collagen in 12 patients with low or undetectable stimulated (postprandial) serum C-peptide levels during 4-8 wk (median, 6 wk) of treatment with constant subcutaneous insulin infusion. Mean plasma fibrinogen, FPA, AT-III, VIIIRCoF , and BTG at baseline were elevated compared with normal. Three patients had heightened platelet responses to ADP that did not correlate to other indicators of a hypercoagulable state; the affected patients, in fact, had significantly lower plasma BTG (25.5 +/- 5.3 [SEM] versus 44.6 +/- 4.6 ng/ml, P less than 0.05) and FPA (1.1 +/- 0.1 versus 2.5 +/- 0.5 ng/ml, P less than 0.05) than the remaining patients. Patients with clinically evident vascular disease had higher baseline plasma BTG and FPA than those without vascular disease (44.6 +/- 5.4 versus 30.2 +/- 4.6, and 2.6 +/- 0.6 versus 1.3 +/- 0.2 ng/ml, P less than 0.05, respectively). During treatment, all patients had declining blood glucose (200 +/- 18 to 102 +/- 5 mg/dl, P less than 0.001) and HbA1 (11.8 +/- 0.6 to 10.2 +/- 0.4%, P less than 0.005). No statistically significant changes in hemostatic functions were noted. During treatment, one patient had an acute myocardial infarction.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsM H Rosove, H J Frank, S S Harwig
JournalDiabetes care (Diabetes Care) 1984 Mar-Apr Vol. 7 Issue 2 Pg. 174-9 ISSN: 0149-5992 [Print] UNITED STATES
PMID6203689 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Beta-Globulins
  • Blood Glucose
  • Hemoglobin A, Glycosylated
  • beta-Thromboglobulin
  • von Willebrand Factor
  • Fibrinopeptide A
  • Platelet Factor 4
  • Adenosine Diphosphate
  • Antithrombin III
  • Fibrinogen
  • Collagen
Topics
  • Adenosine Diphosphate (pharmacology)
  • Adolescent
  • Adult
  • Aged
  • Antithrombin III (analysis)
  • Beta-Globulins (analysis)
  • Blood Glucose (analysis)
  • Child
  • Collagen (pharmacology)
  • Diabetes Mellitus, Type 1 (drug therapy)
  • Female
  • Fibrinogen (analysis, blood)
  • Fibrinopeptide A (blood)
  • Hemoglobin A, Glycosylated (analysis)
  • Humans
  • Insulin Infusion Systems
  • Male
  • Middle Aged
  • Platelet Aggregation (drug effects)
  • Platelet Factor 4 (analysis)
  • Time Factors
  • Vascular Diseases (etiology)
  • beta-Thromboglobulin (analysis)
  • von Willebrand Factor (analysis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: