Capacity of a cis-diammineplatinum[II]-polyglutamic acid complex to cure Trypanosoma congolense infections in mice.

Abstract

A cis-diammineplatinum(II)-polyglutamic acid complex proved to have marked trypanocidal activity in vivo. When 5 mg of platinum per kg was administered daily for 5 days or when 20 mg of platinum per kg was administered on days 1, 3, and 6, five of five treated Trypanosoma congolense-infected mice were cured. In contrast, cis-platin was ineffective at all doses tested. We believe that the complex has a much higher therapeutic ratio than does uncomplexed drug because it is less toxic.

• Authors: S R Meshnick, D Brown, G Smith
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 25 Issue 2 Pg. 286-8 (Feb 1984) ISSN: 0066-4804 [Print] United States
• PMID: 6201136 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptides
• Trypanocidal Agents
• cis-diammineplatinum(II)-polyglutamic acid complex
• Polyglutamic Acid
• Cisplatin

Topics

• Animals
• Cisplatin (adverse effects, analogs & derivatives, chemical synthesis, therapeutic use)
• Kidney Diseases (chemically induced)
• Mice
• Mice, Inbred Strains
• Peptides (therapeutic use)
• Polyglutamic Acid (adverse effects, analogs & derivatives, chemical synthesis, therapeutic use)
• Trypanocidal Agents (adverse effects, chemical synthesis, therapeutic use)
• Trypanosoma congolense
• Trypanosomiasis, African (drug therapy)