Effects of chlordecone exposure on brain neurotransmitters: possible involvement of the serotonin system in chlordecone-elicited tremor.

Abstract

The purpose of this study was to correlate the chlordecone-elicited tremor activity with alterations of brain neurotransmitters. A single injection of chlordecone (80 mg/kg, ip) significantly increased the brain levels of 5-hydroxyindoleacetic acid (5-HIAA) but did not affect the concentrations of dopamine, dihydroxphenylacetic acid, aspartate, taurine, glutamate, glycine, and gamma-aminobutyric acid (GABA). There was a dose- and time-related correlation between the increases in striatal 5-HIAA levels and tremor after chlordecone treatment. A subsequent study with pargyline indicated that the increase in striatal 5-HIAA level represented an increase in the turnover of serotonin. This study plus the previous finding that pizotifen (BC-105), a serotonin receptor blocker, attenuated chlordecone-elicited tremor strongly suggests a possible involvement of the serotonin system in mediating the tremor elicited by this insecticide.

• Authors: J S Hong, H A Tilson, L L Uphouse, J Gerhart, W E Wilson
• Journal: Toxicology and applied pharmacology (Toxicol Appl Pharmacol) Vol. 73 Issue 2 Pg. 336-44 (Apr 1984) ISSN: 0041-008X [Print] United States
• PMID: 6200957 (Publication Type: Journal Article)

Chemical References

• Insecticides
• Neurotransmitter Agents
• 3,4-Dihydroxyphenylacetic Acid
• Serotonin
• Hydroxyindoleacetic Acid
• Pargyline
• Chlordecone
• Dopamine
• Dimethyl Sulfoxide

Topics

• 3,4-Dihydroxyphenylacetic Acid (metabolism)
• Animals
• Body Temperature (drug effects)
• Brain Chemistry (drug effects)
• Chlordecone (toxicity)
• Corpus Striatum (drug effects, metabolism)
• Dimethyl Sulfoxide (pharmacology)
• Dopamine (metabolism)
• Dose-Response Relationship, Drug
• Hydroxyindoleacetic Acid (metabolism)
• Hypothalamus (drug effects, metabolism)
• Insecticides (toxicity)
• Male
• Neurotransmitter Agents (metabolism)
• Pargyline (pharmacology)
• Rats
• Rats, Inbred F344
• Serotonin (metabolism, physiology)
• Tremor (chemically induced, metabolism)